Erythrocyte glutathione levels as long-term predictor of transition to psychosis

S Lavoie; M Berger; M Schlögelhofer; MR Schäfer; S Rice; SW Kim; J Hesse; PD McGorry; S Smesny; GP Amminger

Journal article

Erythrocyte glutathione levels as long-term predictor of transition to psychosis

S Lavoie, M Berger, M Schlögelhofer, MR Schäfer, S Rice, SW Kim, J Hesse, PD McGorry, S Smesny, GP Amminger

Translational Psychiatry | SPRINGERNATURE | Published : 2017

DOI: 10.1038/tp.2017.30

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Abstract

A high proportion of individuals deemed at elevated risk for psychosis will actually never progress to develop the illness. Pharmaceutical intervention may not be necessary in these cases, and may in fact be damaging depending on the invasiveness of the treatment strategy. This highlights the need for biomarkers that are better able to reliably differentiate between at-risk individuals who will subsequently transition to psychosis and those who will not. Low glutathione (GSH) levels have been observed in schizophrenia and in patients with first-episode psychosis. The aim of this study was to determine the predictive value of erythrocyte GSH levels on the transition to psychosis in individual..

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University of Melbourne Researchers

Suzie Lavoie Author

Maximus Berger Author

Simon Rice Author

Patrick McGorry Author

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Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This work was supported by grant 03 T-315 from the Stanley Medical Research Institute. GPA was supported by National Health and Medical Research Council Australia (NHMRC) Senior Research Fellowship (ID: 1080963); PDM was supported by NHMRC Senior Principal Research Fellowship (ID: 1060996); SR was supported by an Early Career Research Fellowship from the Society for Mental Health Research. We thank all the participants and their families.